曾志红，男， 副教授，硕士生导师。湖南省“海智计划工作基地”主任，世界中联李时珍医药研究与应用专业委员会常务理事，湖南省生物化学与分子生物学学会理事。先后在德国（Max Planck Institute for Biophysical Chemistry）、英国萨斯克斯大学(University of Sussex)工作（2001-2019年）。主要研究领域为基因组稳态调控与退行性疾病相关性分子机制及天然小分子活性物质研究，主持湖南省重点研发、省自然科学基金面上等科研项目15项，已在Nature、EMBO、Biochem Pharmacol和J Nanobiotechnology等刊物上发表论文30余篇，获授权国家发明专利3项。

一、发表学术论文（部分）

1. Minzhuo Liu, Shuiqing Wu, Jie Zhang, Jia Yang, Jun Chen, Dariusz C Górecki , Zhihong Zeng#. Anti-breast cancer effects of a novel derivative of biopigment from Serratia marcescens evoked by mitochondrial pathway-mediated apoptosis.Biochem Pharmacol. 2025 Jul 4:241:117123.

2. Efficient enrichment and purification of anti-inflammatory nuezhenoside G13 from Osmanthus fragrans fruit by macroporous resin adsorption Weizhuo Tang, Wenhan Yao, Xiaopeng Lei, Yuqing Zhou, Minzhuo Liu, Zhihong Zeng, Chenxi Zhao. Industrial Crops and Products. 2023 February, 192; 116092.

3. Jie, Zhang,Ziqing Yang, Liquan Luo, Kang Li, Taotao Zi, Junjie Ren, Lei Pan, Ziyue Wang, Zihao Wang, Minzhuo Liu, and Zhihong Zeng. Impact of Poloxamer on Crystal Nucleation and Growth of Amorphous Clotrimazole, Pharmaceutics, 2023,15(8): 2164.

4. Zhang J, Liu M, Xu M, Chen Z, Peng X, Yang Q, Cai T, Zeng Z.Discovery of a new polymorph of clotrimazole through melt crystallization: Understanding nucleation and growth kinetics.J Chem Phys. 2023 Jan 21;158(3):034503.

5. Minzhuo Liu, Shuiqing Wu,Yi Wu, Jie Zhang, Jun Chen, Xucong Peng, Qiusheng Yang, Zhoujin Tan, Zhihong Zeng. Rubus suavissimus S. Lee Extract Alleviates Oxidative Stress and Inflammation in H2O2-Treated Retinal Pigment Epithelial Cells and in High-Fat Diet-Fed Mouse Retinas. Front. Biosci. (Landmark Ed). 2023 Nov 6, 28(11): 279.

6. Zhihong Zeng, Zhou Wang, Simin Chen, Chang Xiao, Minzhuo Liu , Jie Zhang, Jialong Fan, Yanzhong Zhao, Bin Liu. Bio-nanocomplexes with autonomous O2 generation efficiently inhibit Triple Negative Breast Cancer through enhanced chemo-PDT. J Nanobiotechnology. 2022 Nov. 15;20(1):90.

7. Jianrong Chen, Gabrie Mbuta Tchivelekete, Xinzhi Zhou, Weizhuo Tang, Fang liu, Minzhuo Liu, Chenxi Zhao, Xinhua Shu, Zhihong Zeng .Anti-inflammatory activities of Gardenia jasminoides extracts in retinal pigment epithelial cells and in zebrafish embryos. Exp Ther Med. 2021 Jul; 22(1):700.

8. Reem Hasaballah,Alhasani,Mohammad Almarhoun, Xinzhi Zhou , James Reilly,Steven Patterson, Zhihong Zeng. Xinhua Shu.Tauroursodeoxycholic Acid Protects Retinal Pigment Epithelial Cells from Oxidative Injury and Endoplasmic Reticulum Stress In Vitro. Biomedicines. 2020 Sep 21;8(9):367.

9. Biswas L, Ibrahim KS, Li X, Zhou X, Zeng Z, Craft J, Shu X. Effect of a TSPO ligand on retinal pigment epithelial cholesterol homeostasis in high-fat fed mice, implication for age-related macular degeneration. Exp Eye Res. 2021 Jul;208:108625.

10. Polo LM, Xu Y, Hornyak P, Garces F, Zeng Z, Hailstone R, Matthews SJ, Caldecott KW, Oliver AW, Pearl LH. Efficient Single-Strand Break Repair Requires Binding to Both Poly(ADP-Ribose) and DNA by the Central BRCT Domain of XRCC1. Cell Rep. 2019 Jan 15;26(3):573-581.

11. Zeng Z, Rulten SL, Breslin C, Zlatanou A, Coulthard V, Caldecott KW Acylpeptide hydrolase is a component of the cellular response to DNA damage. DNA Repair (Amst). 2017 Oct; 58:52-61.

12. Hoch NC, Hanzlikova H, Rulten SL, Tétreault M, Komulainen E, Ju L, Hornyak P, Zeng Z, Gittens W, Rey SA, Staras K, Mancini GM, McKinnon PJ, Wang ZQ, Wagner JD; Care4Rare Canada Consortium, Yoon G, Caldecott KW. XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia. Nature. 2017 Jan 5;541(7635):87-91.

13. Grundy GJ, Polo LM, Zeng Z, Rulten SL, Hoch NC, Paomephan P, Xu Y, Sweet SM, Thorne AW, Oliver AW, Matthews SJ, Pearl LH, Caldecott KW PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2) . Nat Commun. 2016 Aug 17; 7:12404.

14. Grundy GJ, Rulten SL, Zeng Z, Arribas-Bosacoma R, Iles N, Manley K, Oliver A, Caldecott KW.APLF promotes the assembly and activity of non-homologous end joining protein complexes.EMBO J. 2013 Jan 9;32(1):112-25.

15. Gómez-Herreros F, Romero-Granados R, Zeng Z, Alvarez-Quilón A, Quintero C, Ju L, Umans L, ermeire L, Huylebroeck D, Caldecott KW, Cortés-Ledesma F. TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo. PLoS Genet. 2013;9(3):

16. Zeng Z, Sharma A, Ju L, Murai J, Umans L, Vermeire L, Pommier Y, Takeda S, Huylebroeck D, Caldecott KW, El-Khamisy SF.TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.Nucleic Acids Res. 2012 Sep; 40(17):8371-80.

17. Zeng Z, Cortés-Ledesma F, El Khamisy SF, Caldecott KW. TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage. J Biol Chem. 2011 Jan 7;286(1):403-9.

18. Iijima J, Zeng Z, Takeda S, Taniguchi Y RAP80 acts independently of BRCA1 in repair of topoisomerase II poison-induced DNA damage.Cancer Res. 2010 Nov 1;70(21):8467-74.

（更新时间： 2026 年 4 月）