张杰，男，博士，副教授，硕士生导师。主持国家自然科学基金1项，湖南省优青、中国博士后科学基金特别资助等省部级项目4项，公开发表SCI论文20余篇，获国家发明专利2件，获“卡乐康”奖教金1项。目前主要研究方向为难溶性药物结晶和固体分散体开发。

一、发表学术论文（部分）

1.Jie Zhang*, Luna Zhang, Minzhuo Liu, Zhihong Zeng. Impact of Surfactants as Formulation Additives and Media Components on the Performance of Amorphous Solid Dispersions, Crystal Growth & Design, 2025, 25, 14, 5561–5583.

2.Jia Xu; Hongjian Ji; Guozhe Zhang; Jin Cheng; Qin Shi; Jie Zhang*. Virtual screening and experimental validation of luteolin cocrystals for enhanced solubility, Journal of Molecular Structure, 2025, 1337(15) :142207.

3.Jie Zhang, Qiusheng Yang, Meixia Xu, Xinqiang Tan, Xucong Peng, Ziqing Yang, Kang Li, Jia Yang, Jie Chen, Xuan Xun, et al. Accelerating Effects of Poloxamer and Its Structural Analogs on the Crystallization of Nitrendipine Polymorphs, Pharmaceuticals, 2025, 18, 1000.

4.Jie Zhang*, Qing Jiang, Zhenling Xu, Qianqian Yang, Gangqiang Hao, Minzhuo Liu*, Zhihong Zeng*; Recent Progress on Crystal Nucleation of Amorphous Solid Dispersion, Crystal Growth & Design, 2024, 24, 8655−8666.

5.Jie Zhang, Ziqing Yang, Liquan Luo, Kang Li, Taotao Zi, Junjie Ren, Lei Pan, Ziyue Wang, Zihao Wang, Minzhuo Liu,* and Zhihong Zeng*; Impact of Poloxamer on Crystal Nucleation and Growth of Amorphous Clotrimazole, Pharmaceutics, 2023, 15(8): 2164.

6.Jie Zhang, Minshan Guo, Minqian Luo, Ting Cai*; Advances in the Development of Amorphous Solid Dispersions: the Role of Polymeric Carriers, Asian Journal of Pharmaceutical Sciences, 2023, 18, 100834.

7.Jie Zhang*, Meixia Xu, Shuiqing Wu, Zhiguo Chen, Liquan Luo, Taotao Zi, Xucong Peng, Qiusheng Yang, Minzhuo Liu,* and Zhihong Zeng*, Investigation into Surface Effects on the Crystal Nucleation and Growth of Clotrimazole Polymorphs, Crystal Growth & Design, 2023, 23, 3535-3543.

8.Jie Zhang#, Minzhuo Liu#, Zhihong Zeng; Discovery of a new polymorph of clotrimazole through melt crystallization: Understanding nucleation and growth kinetics, The Journal of Chemical Physics, 2023, 158, 034503.

9.Jie Zhang#, Minzhuo Liu#, Zhihong Zeng; The antisolvent coprecipitation method for enhanced bioavailability of poorly water-soluble drugs, International Journal of Pharmaceutics, 2022, 626, 122043.

10.Jie Zhang#, Qin Shi#, Tengfei Qu, Dongshan Zhou, Ting Cai; Crystallization Kinetics and Molecular Dynamics of Binary Coamorphous Systems of Nimesulide and Profen Analogues, International Journal of Pharmaceutics, 2021 ,610,121235.

11.Jie Zhang#, Zhengyu Liu#, Haomin Wu, Ting Cai*; Effect of polymeric excipients on nucleation and crystal growth kinetics of amorphous fluconazole, Biomaterials Science, 2021, 9, 4308–4316.

12.Jie Zhang, Qin Shi, Minshan Guo, Zhengyu Liu,Ting Cai*; Melt Crystallization of Indomethacin Polymorphs in the Presence of Poly(ethylene oxide): Selective Enrichment of Polymer at the Crystal-Liquid Interface, Molecular Pharmaceutics, 2020, 17: 2064-2071.

13.Jie Zhang, Qin Shi, Jun Tao, Yayun Peng, Ting Cai*; Impact of Polymer Enrichment at the Crystal–Liquid Interface on Crystallization Kinetics of Amorphous Solid Dispersions, Molecular Pharmaceutics, 2019, 16: 1385-1396.

14.张杰,蔡挺*. 无定形态药物制备技术研究进展[J].药学进展,2018,9 (42), 675-684.

15.张杰, 孙敏捷, 平其能*, 等. 芒果苷-磷脂复合物的油制剂在大鼠灌胃后的生物利用度[J]. 中国新药杂志, 2014, 9: 023.

三、主持课题项目（部分）

(1) 国家自然科学基金青年项目，基于分子相互作用和运动性的固体分散体成核机制及处方设计策略研究（经费 30 万元，项目编号：82304460），在研。

(2) 湖南省优秀青年科学基金项目，难溶性药物固体分散体成核机理与处方设计策略研究（经费 20 万元，项目编号：2024JJ4003），在研。

(3) 江苏省自然科学基金青年项目，无定形态药物结晶成核机制及提高物理稳定性策略研究（经费 20 万元，项目编号：BK20200573），已结题。

(4) 中国博士后科学基金特别资助项目，口腔速溶技术改善新冠肺炎合并基础疾病患者服药顺应性的研究（经费 18 万元，项目编号：2020T130139ZX），已结题。

(5) 湖南省教育厅优秀青年项目，基于干预无定形药物成核调控克霉唑新晶型形成的研究（经费 3 万元，项目编号：22B0820），已结题。

四、获奖

卡乐康奖教金一项。

五、联系信息

E-mail: zhangjie448215@163.com

（更新时间：2026年4月）